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Mark R Middleton Selected Research

Protein Kinases (Protein Kinase)

1/2021Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours.

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Mark R Middleton Research Topics

Disease

54Melanoma (Melanoma, Malignant)
05/2022 - 08/2002
51Neoplasms (Cancer)
01/2022 - 01/2003
13Neoplasm Metastasis (Metastasis)
01/2022 - 05/2014
6Disease Progression
12/2019 - 06/2007
5Brain Neoplasms (Brain Tumor)
01/2022 - 10/2015
5Adenocarcinoma
01/2020 - 07/2012
4Fatigue
01/2020 - 01/2003
4Diarrhea
01/2019 - 01/2003
3Pancreatic Neoplasms (Pancreatic Cancer)
04/2021 - 07/2012
3Drug-Related Side Effects and Adverse Reactions
11/2020 - 05/2014
3Vomiting
01/2020 - 07/2013
3Exanthema (Rash)
01/2020 - 07/2012
3Hyperthermia
01/2019 - 01/2017
3Breast Neoplasms (Breast Cancer)
01/2019 - 01/2018
3Colorectal Neoplasms (Colorectal Cancer)
12/2018 - 01/2010
3Neutropenia
01/2018 - 07/2013
2Glioblastoma (Glioblastoma Multiforme)
01/2022 - 01/2010
2Colitis
10/2021 - 11/2020
2Lymphoma (Lymphomas)
07/2021 - 01/2019
2Stomach Neoplasms (Stomach Cancer)
01/2020 - 05/2019
2Esophageal Neoplasms (Esophageal Cancer)
12/2019 - 02/2017
2Barrett Esophagus (Barrett's Esophagus)
07/2016 - 01/2016
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2016 - 08/2014
2Prostatic Neoplasms (Prostate Cancer)
10/2014 - 01/2010
1Inflammation (Inflammations)
01/2022
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021
1Uveal melanoma
11/2020
1Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
11/2020
1Pneumonia (Pneumonitis)
11/2020
1Liver Diseases (Liver Disease)
10/2019
1Hepatitis
10/2019
1Cholangitis
10/2019

Drug/Important Bio-Agent (IBA)

15IpilimumabIBA
05/2022 - 01/2012
10Pharmaceutical PreparationsIBA
10/2019 - 01/2012
9Immune Checkpoint InhibitorsIBA
05/2022 - 01/2016
9Proteins (Proteins, Gene)FDA Link
07/2021 - 05/2005
9DNA (Deoxyribonucleic Acid)IBA
01/2020 - 06/2004
8NivolumabIBA
05/2022 - 11/2017
8Biomarkers (Surrogate Marker)IBA
10/2021 - 03/2014
7Temozolomide (Temodar)FDA LinkGeneric
11/2015 - 08/2002
6VemurafenibIBA
01/2017 - 01/2012
5dabrafenibIBA
01/2021 - 05/2013
5Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
02/2015 - 07/2012
4pembrolizumabIBA
05/2022 - 11/2017
4InterferonsIBA
01/2021 - 11/2010
3RNA (Ribonucleic Acid)IBA
10/2021 - 01/2021
3trametinibIBA
01/2021 - 07/2012
3Bevacizumab (Avastin)FDA Link
11/2020 - 05/2014
3Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2020 - 09/2012
3GemcitabineFDA Link
01/2014 - 08/2003
3lomeguatribIBA
01/2010 - 03/2006
2Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
01/2022 - 01/2019
2AntigensIBA
11/2021 - 11/2020
2Histone Deacetylase InhibitorsIBA
07/2021 - 01/2019
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2020 - 05/2014
2AntibodiesIBA
11/2020 - 10/2014
2Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
12/2019 - 05/2019
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2019 - 01/2018
2talimogene laherparepvecIBA
01/2019 - 09/2015
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
01/2019 - 09/2015
2Estrogen ReceptorsIBA
01/2019 - 01/2018
2AlpelisibIBA
01/2019 - 01/2018
2ErbB Receptors (EGF Receptor)IBA
01/2018 - 01/2016
2rucaparibIBA
03/2017 - 05/2013
2Carboplatin (JM8)FDA LinkGeneric
03/2017 - 08/2003
2Cyclin B1IBA
11/2016 - 05/2013
2Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2016 - 09/2015
2CH 4987655IBA
08/2014 - 09/2012
2Dacarbazine (DIC)FDA LinkGeneric
07/2013 - 01/2003
2MethyltransferasesIBA
12/2011 - 06/2007
2Alkylating AgentsIBA
08/2006 - 01/2003
1Gadolinium DTPA (Magnevist)FDA Link
01/2022
1Janus Kinase InhibitorsIBA
10/2021
1tofacitinibIBA
10/2021
1Interferon-gamma (Interferon, gamma)IBA
10/2021
1AcetylesteraseIBA
07/2021
1Histones (Histone)IBA
07/2021
1VX (EDIM)IBA
01/2021
1A 121IBA
01/2021
1Protein Kinases (Protein Kinase)IBA
01/2021
1berzosertibIBA
01/2021
1tebentafuspIBA
11/2020
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
11/2020
1CytokinesIBA
11/2020
1cyclopropapyrroloindoleIBA
01/2020
1AZD 8931IBA
01/2020
1XELOXIBA
01/2020
1Capecitabine (Xeloda)FDA Link
01/2020
1Alanine Transaminase (SGPT)IBA
10/2019
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2019
1Programmed Cell Death 1 ReceptorIBA
10/2019
1SteroidsIBA
10/2019
1Infliximab (Remicade)FDA Link
10/2019

Therapy/Procedure

29Therapeutics
05/2022 - 12/2005
15Drug Therapy (Chemotherapy)
01/2020 - 06/2004
5Immunotherapy
11/2021 - 09/2015
5Radiotherapy
11/2019 - 09/2012
4Neoadjuvant Therapy
12/2019 - 10/2016
2Adjuvant Chemotherapy
02/2014 - 07/2012
1Intravenous Administration
01/2022